by University of Portsmouth, School of Pharmacy and Biomedical Sciences in Portsmouth .
Written in English
Thesis (Ph.D.) - University of Portsmouth, 1998.
|Statement||Lesley Jane Adams.|
Pyrrolo[1,4]benzodiazepines are tricyclic compounds that are considered “privileged structures” since they possess a wide range of biological activities. The first encounter with these molecules was the isolation of anthramycin from cultures of Streptomyces, followed by determination of the X-ray crystal structure of the molecule and a study of its interaction with by: Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates Article in Bioorganic & Medicinal Chemistry 13(6) April with 10 Reads. Antonow D, Kaliszczak M, Kang G-D et al () Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepines (PBD) antitumour agents. J Med Chem – CrossRef PubMed Google ScholarCited by: 1. Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs)Cited by: 2.
The invention claimed is: 1. A compound which is A: where R 10 and R 11 either (a) form a double bond between the carbon and nitrogen atoms to which they are bound; or (b) are H and OR A respectively, where R A is selected from H and C alkyl; or a pharmaceutically acceptable salt thereof. 2. A conjugate selected from the group consisting of formula ConjA: ConjB: and ConjC: wherein CBA Cited by: Many natural and synthetic anticancer agents with the ability to interact with DNA have been discovered, but most have little sequence-specificity and often exhibit severe toxicity to normal tissues. Thus, there has been considerable interest in molecular biology and human medicine to find small molecules that can alkylate the DNA in a sequence-specific manner and modify the function of Cited by: Adams et al., “Molecular modelling of a sequence-specific DNA-binding agent based on the pyrrolo[2,1-c][1,4]benzodiazepines,” Pharm. Pharmacol. AbstractA new, selective and sensitive HPLC method for the determination of lixivaptan, an oral selective vasopressin 2 (V2)-receptor antagonist, was investigated and validated. A Waters symmetry C18 column was used as a stationary phase in isocratic elution mode using a mobile phase composed of KH2PO4 ( mM)-acetonitrile ( 60, v/v) at a flow rate of mL minAuthor: Haitham Alrabiah, Mohammed Abunassif, Sabry Attia, Gamal Abdel-Hafiz Mostafa.
Chapter 3 on Intermolecular Forces and Molecular Modelling has required expansion and revision due to advances in the techniques relating to ligand-receptor interactions and we are indebted to Zeneca, through Dr , for their generosity in meeting the considerable cost of reproducing the necessary new colour plates in the book. CROSS-REFERENCE TO RELATED APPLICATIONS. This application is a continuation of copending U.S. application Ser. No. 15/,, filed on Dec. 19, , now U.S. Pat. The vibrational spectra of uracil derivatives have been studied by several workers, recent studies being those of Rastogi et al and Palafox et al .. The nucleic acid bases with sulphur atom instead of oxygen atom have been a subject of considerable interest since they were detected in natural t-RNAs. Molecular modeling studies such as molecular docking and pharmacophore generation were performed with known NK1R antagonists and BSN by using Discovery Studio (DS) by Accelrys to explain their binging modes to NK1R4 (Figure ).